Category: health

July 15: India’s pharmaceutical sector is witnessing a strong rise in innovation activity, with India-origin pharma patents registering significant growth and the industry’s research pipeline expanding to more than 1,095 projects, according to a recent report. The increase in patent filings reflects the growing focus of Indian pharmaceutical companies on…

Guwahati, July 10: The Assam government has presented a budget focused on employment generation, infrastructure development, healthcare improvement, and overall economic growth, outlining 10 major initiatives aimed at strengthening the state’s development agenda. The budget places strong emphasis on creating new job opportunities, supporting youth, and enhancing skill development programmes.…

New Delhi, July 10: The government has announced that formulations containing high levels of alcohol will require appropriate licences and prescriptions to ensure regulated use and prevent misuse.  Pic Credit: Pexel The move aims to strengthen oversight of alcohol-based medicinal and healthcare products by bringing stricter controls on their manufacturing,…

Milan, Italy, July 08 — Genespire, in collaboration with researchers at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), has today announced the publication of preclinical data supporting the potential of its liver-directed immune-shielded lentiviral gene therapy approach to treat methylmalonic acidemia (MMA), a severe inherited metabolic disorder. The findings, published in the Journal of Hepatology, show that a single systemic administration of a lentiviral vector encoding the MMUT gene led to sustained improvements in disease features in a validated mouse model of MMA, with effects lasting for the average lifespan of laboratory mice. Since the mice were treated when young, the study supports the durability of the gene therapy through postnatal growth and maturation of the liver. MMA is caused by a deficiency of methylmalonyl-CoA mutase, an enzyme that plays a critical role in the body’s metabolism of food. Its absence results in the accumulation of toxic metabolites that lead to recurrent metabolic crises, growth failure, neurological impairment, and multi-organ damage. In the study, researchers also treated mice with a dose containing an optimized MMUT transgene, thereby improving therapeutic efficacy. In the same mouse model of MMA, this version exhibited a dose-dependent improvement of metabolomic biomarkers, with gene transfer efficiency exceeding 80% of the liver. The study also highlights that genetically corrected cells in the liver may, over time, replace the diseased ones, suggesting that therapeutic efficacy may progressively improve even when starting at lower initial doses. “Together, these findings indicate that Genespire is on a clear path towards the long-term correction of metabolic diseases which impact the liver and other organs,” said Lucia Faccio, CEO of Genespire. “We believe our approach has the potential to translate into human health in the form of a single-administration treatment for patients with MMA, and are committed to continuing our efforts in bringing our lead asset for MMA, GENE202, to the clinic. We would like to extend our gratitude to everyone involved in the research project, especially those at the SR-TIGET.” “We are confident that this study, together with other previous studies from our group at SR-TIGET, provides a comprehensive pre-clinical data package enabling the initiation of clinical testing in pediatric patients affected by MMA” concludes Dr Alessio Cantore, group leader at SR-TIGET and Associate Professor at Vita-Salute San Raffaele University, who supervised and coordinated the study and signed it as senior author.

Bhopal, July 8: The Madhya Pradesh Government is working to expand digital healthcare services to the remotest parts of the state under the Ayushman Bharat Digital Mission (ABDM), with the aim of improving access to quality and affordable healthcare through technology. The initiative focuses on strengthening digital health infrastructure and…

Lucknow, July 8: The Uttar Pradesh government has launched a new cashless healthcare scheme aimed at providing easier and more accessible medical treatment facilities to teachers and employees working in the education sector. Under the initiative, eligible teachers and education department staff will be able to avail cashless medical services…

New Delhi, July 8: The Government has approved Navi Mumbai International Airport as an authorised point for importing medicines into India, providing pharmaceutical companies with an additional gateway for drug shipments. The decision will help improve the movement of medicines by offering better logistics support, faster transportation and more options…

Gandhinagar, July 7: Health facilities across Gujarat have removed more than five lakh unused and obsolete items as part of a statewide cleanliness campaign aimed at improving hygiene and strengthening healthcare management. The drive focused on clearing unnecessary materials, outdated equipment, and unused resources from hospitals and health centres to…

July 6: The Ayushman Bharat Digital Mission (ABDM) has achieved a major milestone by linking over 104 crore health records across its digital health ecosystem. The initiative aims to create a unified and secure digital health infrastructure in India, enabling individuals to access and manage their health records seamlessly across healthcare…

  Hyderabad, July 6: A significant milestone in healthcare was marked today with the grand inauguration of Pranadhara Children’s Hospital & Nyra Fertility at Chintal, Hyderabad, dedicated to providing specialized pediatric and fertility care to families in Hyderabad and surrounding areas. The facility was formally inaugurated by Dr. Preeti Reddy,…