Modular Chemoenzymatic Platform Streamlines Production of Six Medicinal Alkaloids from Huanglian

Berberine, palmatine, jatrorrhizine, and other protoberberine alkaloids (PBAs) from Huanglian exhibit potent antimicrobial, anti-inflammatory, and anticancer activities. Yet their structural complexity makes scalable production challenging. Plant extraction depends on crop cycles and climate, while chemical synthesis suffers from low regioselectivity and harsh conditions. Heterologous biosynthesis in microbes has been hindered by…

Continue Reading